Histological transformation from non-small cell to small cell lung carcinoma

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Histological transformation from non-small cell to small cell lung carcinoma

To cite: Haruta(Inoue) Y, Kataoka Y, Nikaido J, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/ bcr-2016-216232 DESCRIPTION A 58-year-old woman with no history of smoking was admitted to our hospital with exacerbation of cough. CT of the chest revealed a left upper lobe lung tumour. Bronchoscopic biopsy of the tumour revealed stage IV poorly differentiated ade...

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Histological transformation from non-small cell to small cell lung carcinoma after treatment with epidermal growth factor receptor-tyrosine kinase inhibitor

Several cases of acquired resistance in patients with activating epidermal growth factor receptor (EGFR) mutation have been reported. However, rare clinical cases exist of a transformation to small cell lung cancer (SCLC) following treatment with EGFR-tyrosine kinase inhibitors (TKIs). We report a case of non-small cell lung cancer (NSCLC) with L858R mutation at the time of diagnosis. After fai...

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A Case Report of Small Cell Lung Carcinoma in a Patient with Progressive Diffuse Sclerosis

 Connective tissue diseases, including scleroderma, may be associated with an increased risk of lung cancer. The most common type of lung cancer associated with systemic sclerosis is adenocarcinoma or bronchoalveolar carcinoma, and small cell carcinoma is rare. This reports presents a 54-year-old non-smoker woman with a history of scleroderma who was examined due to aggravation of shortness of ...

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Matrix metalloproteinase-9 (MMP-9) Expression in Non-Small Cell Lung Carcinoma and Its Association with Clinicopathologic Factors

Background & Objective:  Matrix metalloproteinases-9 (MMP-9) is one of the most important enzymes to breakdown extracellular matrix which plays a major role in tumor invasion and metastasis. This study aimed to determine tumor MMP-9 expression in non-small-cell lung carcinoma (NSCLC) and whethe...

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ژورنال

عنوان ژورنال: BMJ Case Reports

سال: 2016

ISSN: 1757-790X

DOI: 10.1136/bcr-2016-216232